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5-Bromo-6-fluoroisoindoline hydrochloride

  • CAS No. 2768326-58-3

  • Cat. No. CS-1048715
  • Molecule weight252.51
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Bromo-6-fluoroisoindoline hydrochloride|CS-1048715

Structure of 2768326-58-3

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General Information

  • CAS No. 2768326-58-3
  • Cat. No. CS-1048715
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈BrClFN
  • Molecular Weight 252.51
  • Synonym(s) None
  • SMILES FC1=C(Br)C=C(CNC2)C2=C1.Cl

Description

5-Bromo-6-fluoroisoindoline (hydrochloride) delivers a uniquely functionalized heterocyclic scaffold featuring complementary halogen substituents at adjacent positions. This bench-stable, moisture-tolerant building block enables direct coupling in cross-coupling reactions and facilitates the construction of complex pharmaceutical intermediates through palladium-catalyzed transformations.

Application

5-Bromo-6-fluoroisoindoline (hydrochloride) serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted isoindoline scaffolds. The bromo and fluoro substituents provide orthogonal handles for palladium-catalyzed cross-coupling and electrophilic functionalization. Its hydrochloride salt enhances bench stability and solubility, facilitating purification and handling in standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   2.6132
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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