CRBN ligand-109

Name: CRBN ligand-109
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 2758533-77-4
Cat. No. CS-0435062
Purity≥95%
MDL No.None

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 2758533-77-4

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 2758533-77-4
Cat. No. CS-0435062
Purity ≥95%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₈BrF₂NO₂
Molecular Weight 304.09
Synonym(s) None
SMILES O=C(C(C1=C(F)C=C(Br)C=C1F)CC2)NC2=O

Description

CRBN ligand-109 is a potent, bench-stable small molecule that selectively engages the CRL4^CRBN E3 ubiquitin ligase complex. This compound integrates a unique heterocyclic scaffold designed to enhance target protein recruitment, enabling efficient degradation of disease-relevant proteins in cellular models.

Application

CRBN ligand-109 serves as a well-characterized molecular glue ligand for the CRL4^CRBN E3 ubiquitin ligase complex, enabling targeted protein degradation of specific substrates. It functions as a potent and selective recruiter of disease-relevant proteins to the ubiquitin-proteasome system, facilitating their degradation in cellular models. The compound exhibits favorable bench stability, moderate solubility, and compatibility with standard synthetic workflows, supporting its use in PROTAC development and target validation studies.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 46.17
LogP 2.2833
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Life Science PROTAC Ligands for E3 Ligase

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

Drug Discovery Cancer EGFR

Key Words

CRBN ligand-109 sigmaCRBN ligand-109 manufacturerCRBN ligand-109 priceCRBN ligand-109 structureCRBN ligand-109 SDSbuy CRBN ligand-109CRBN ligand-109 supplierCRBN ligand-109 usesCRBN ligand-109 molecular weightprice of CRBN ligand-109CRBN ligand-109 chemical name formula of CRBN ligand-109

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

CRBN ligand-109

CAS No. 2758533-77-4

Recommended Products