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CS-W001157 4
Total: USD 88.00

1,8-Naphthyridine-2-carboxylic acid

  • CAS No. 215523-34-5

  • Cat. No. CS-0043745
  • Purity≥97%
  • MDL No.MFCD00202900

*For research and further manufacturing use only, not for direct human use.

1,8-Naphthyridine-2-carboxylic acid|CS-0043745

Structure of 215523-34-5

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General Information

  • CAS No. 215523-34-5
  • Cat. No. CS-0043745
  • Purity ≥97%
  • MDL No. MFCD00202900
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆N₂O₂
  • Molecular Weight None
  • Synonym(s) 2-Carboxy-1,8-naphthyridine
  • SMILES O=C(C1=NC2=NC=CC=C2C=C1)O

Description

1,8-Naphthyridine-2-carboxylic acid features a rigid, electron-deficient heteroaromatic core paired with a carboxylic acid handle, enabling direct conjugation in metal coordination and bioconjugation workflows. This bench-stable scaffold integrates readily into ligand design for catalysis and pharmaceutical development.

Application

1,8-Naphthyridine-2-carboxylic acid serves as a versatile scaffold for medicinal chemistry and catalytic applications, offering a rigid, planar heterocyclic core with orthogonal functionalization potential. The carboxylic acid group enables direct coupling reactions, while the naphthyridine framework provides enhanced solubility and favorable binding interactions in target-directed synthesis. Its bench-stable nature and compatibility with standard peptide coupling protocols facilitate efficient derivatization for probe development and API intermediates.

Synthesis

  • Route1
    • null|null
      85191-50-0
    • ~51%
    • In-stock
      1,8-Naphthyridine-2-carboxylic acid|CS-0043745
      215523-34-5

    References

    • Mogilaiah, K.; Vijayender Reddy, K.; Sreenivasulu, B. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 2 p. 178 - 179
  • Route2

    References

    • Synlett, , # 3 p. 379 - 382
  • Route3
    • null|null
      125902-24-1
    • ~%
    • In-stock
      1,8-Naphthyridine-2-carboxylic acid|CS-0043745
      215523-34-5

    References

    • Journal of Organic Chemistry, , vol. 55, # 9 p. 2838 - 2842

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   63.08
  • LogP   1.328
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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