(R)-1-Fluoropropan-2-amine hydrochloride

Name: (R)-1-Fluoropropan-2-amine hydrochloride
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CAS No. 273734-17-1
Cat. No. CS-0104382
Molecule weight113.56
Purity≥95%
MDL No.MFCD30188513

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(R)-1-Fluoropropan-2-amine hydrochloride|CS-0104382

Structure of 273734-17-1

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General Information

CAS No. 273734-17-1
Cat. No. CS-0104382
Purity ≥95%
MDL No. MFCD30188513
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃H₉ClFN
Molecular Weight 113.56
Synonym(s) None
SMILES C[C@@H](N)CF.[H]Cl

Description

(R)-1-Fluoropropan-2-amine hydrochloride is a chiral amine intermediate featuring a fluorinated carbon adjacent to the amine group. This configuration enables selective incorporation into bioactive molecules, particularly in medicinal chemistry applications requiring stereocontrol. The hydrochloride salt form enhances solubility and stability under standard bench conditions, facilitating handling in synthesis workflows.

Application

(R)-1-Fluoropropan-2-amine hydrochloride serves as a valuable chiral building block for the synthesis of fluorinated pharmaceutical intermediates and bioactive molecules. Its bench-stable, crystalline form facilitates handling and purification, while the primary amine functionality enables straightforward derivatization via amidation, alkylation, and reductive amination. The stereochemical integrity of the (R)-enantiomer supports enantioselective synthesis in medicinal chemistry workflows.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Computational Chemistry Data

TPSA 26.02
LogP 0.7249
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Fatty chain compounds

Key Words

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(R)-1-Fluoropropan-2-amine hydrochloride

CAS No. 273734-17-1

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