Lot numbers can be found on the outside label of a product:
(R)-1-(4-Chlorophenyl)ethanamine
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CAS No. 27298-99-3
- Cat. No. CS-0000291
- Purity≥97%
- MDL No.MFCD00671639
*For research and further manufacturing use only, not for direct human use.
Structure of 27298-99-3
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General Information
- CAS No. 27298-99-3
- Cat. No. CS-0000291
- Purity ≥97%
- MDL No. MFCD00671639
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₁₀ClN
- Molecular Weight 155.62
- Synonym(s) (R)-4-Chloro-alpha-methylbenzylamine~ClophaR(tm
- SMILES N[C@H](C)C1=CC=C(Cl)C=C1
Description
(R)-1-(4-Chlorophenyl)ethanamine is a chiral amine featuring a para-chlorinated phenyl group attached to a stereodefined ethylamine scaffold. This bench-stable compound serves as a key enantiomerically pure building block in asymmetric synthesis, particularly for pharmaceutical intermediates and ligands in catalytic systems. The aryl moiety enhances π-interaction potential, while the (R)-configuration enables precise stereocontrol in downstream transformations.
Application
(R)-1-(4-Chlorophenyl)ethanamine serves as a chiral building block for the synthesis of pharmaceutically relevant aryl ethylamine derivatives. Its well-defined stereochemistry enables stereoselective transformations in medicinal chemistry applications. The molecule exhibits good bench stability and functional group tolerance, facilitating straightforward incorporation into diverse synthetic routes, including amide coupling and reductive amination. It functions effectively as a precursor in the construction of bioactive heterocycles and API intermediates.
Synthesis
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Route1
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937371-83-0 - ~90%
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In-stock
27298-99-3
References
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Pakulski, Marcin M.; Mahato, Sanjit K.; Bosiak, Mariusz J.; Krzeminski, Marek P.; Zaidlewicz, Marek Tetrahedron Asymmetry, 2012 , vol. 23, # 9 p. 716 - 721
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Route2
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99-91-2
- ~%
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In-stock
4187-56-8 -
In-stock
27298-99-3
References
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Xie, Ying; Pan, Hongjie; Xiao, Xiao; Li, Songlei; Shi, Yian Organic and Biomolecular Chemistry, 2012 , vol. 10, # 45 p. 8960 - 8962,3 Title/Abstract Full Text Show Details Xie, Ying; Pan, Hongjie; Xiao, Xiao; Li, Songlei; Shi, Yian Organic and Biomolecular Chemistry, 2012 , vol. 10, # 45 p. 8960 - 8962
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Route3
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35588-60-4
- ~0%
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In-stock
4187-56-8
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In-stock
27298-99-3
References
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Mereyala, Hari Babu; Fatima, Liyakat; Pola, Pallavi Tetrahedron Asymmetry, 2004 , vol. 15, # 4 p. 585 - 587
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS05,GHS06,GHS09
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Signal Word : Danger
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UN#: 2810
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301+H311+H331-H315-H317-H318-H410
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Precautionary Statements : P261-P273-P280
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Quality Control
Computational Chemistry Data
- TPSA 26.02
- LogP 2.3597
- H_Acceptors 1
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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