Lot numbers can be found on the outside label of a product:
1H-Pyrazolo[4,3-b]pyridine
-
CAS No. 272-52-6
- Cat. No. CS-W003469
- Purity≥98%
- MDL No.MFCD08234560
*For research and further manufacturing use only, not for direct human use.
![1H-Pyrazolo[4,3-b]pyridine|CS-W003469](https://file.chemscene.com/productPIC/CS-W003469.gif)
Structure of 272-52-6
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 272-52-6
- Cat. No. CS-W003469
- Purity ≥98%
- MDL No. MFCD08234560
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₅N₃
- Molecular Weight 119.12
- Synonym(s) PYRAZOLOPYRIDINE
- SMILES c1cnc2c(c1)[nH]nc2
Description
1H-Pyrazolo[4,3-b]pyridine is a nitrogen-rich heterocycle featuring fused pyrazole and pyridine rings, offering enhanced planarity and electron-deficient character. This scaffold integrates readily into bioactive molecules, enabling strong π-stacking interactions and improved metabolic stability in pharmaceutical applications.
Application
1H-Pyrazolo[4,3-b]pyridine serves as a privileged heterocyclic scaffold in medicinal chemistry, enabling efficient access to bioactive molecules through its inherent planarity and hydrogen-bonding capacity. The core structure exhibits robust bench stability and compatibility with common coupling reactions, facilitating functionalization at multiple positions. Its utility spans catalytic transformations and modular synthesis of kinase inhibitors, GPCR modulators, and other pharmaceutical intermediates.
Synthesis
-
Route1
-
![1-(1h-Pyrazolo[4,3-b]pyridin-1-yl)ethan-1-one|CS-0666616](https://file.chemscene.com/productPIC/CS-0666616.gif)
52090-62-7 - ~94%
-
In-stock
272-52-6
References
-
F. HOFFMANN-LA ROCHE AG; CHEN, Shaoqing; DE VICENTE FIDALGO, Javier; HAMILTON, Matthew Michael; HERMANN, Johannes Cornelius; KENNEDY-SMITH, Joshua; LI, Hongju; LOVEY, Allen John; LUCAS, Matthew C.; LUK, Kin-Chun Thomas; LYNCH, Stephen M.; O'YANG, Counde; PADILLA, Fernando; SCHOENFELD, Ryan Craig; SIDDURI, Achyutharao; SOTH, Michael; WANG, Ce; WOVKULICH, Peter Michael; ZHANG, Xiaohu Patent: WO2013/30138 A1, 2013 ; Location in patent: Page/Page column 253 ;
-
-
Route2
-
In-stock
31224-43-8 - ~60%
-
In-stock
272-52-6
References
-
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT Patent: WO2008/71451 A1, 2008 ; Location in patent: Page/Page column 52 ; WO 2008/071451 A1
-
-
Route3
-
In-stock
372-47-4 - ~%
-
In-stock
272-52-6
References
-
Herdemann, Matthias; Weber, Alexander; Jonveaux, Jerome; Schwoebel, Frank; Stoeck, Michael; Heit, Isabelle Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 6 p. 1852 - 1856
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H319-H335
|
|
|
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 41.57
- LogP 0.9579
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 0
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 1H-Pyrazolo[4,3-b]pyridine sigma1H-Pyrazolo[4,3-b]pyridine manufacturer1H-Pyrazolo[4,3-b]pyridine price1H-Pyrazolo[4,3-b]pyridine structure1H-Pyrazolo[4,3-b]pyridine SDSbuy 1H-Pyrazolo[4,3-b]pyridine1H-Pyrazolo[4,3-b]pyridine supplier1H-Pyrazolo[4,3-b]pyridine uses1H-Pyrazolo[4,3-b]pyridine molecular weightprice of 1H-Pyrazolo[4,3-b]pyridine1H-Pyrazolo[4,3-b]pyridine chemical name formula of 1H-Pyrazolo[4,3-b]pyridine