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CS-W001157 4
Total: USD 88.00

1-(Benzylamino)propan-2-ol

  • CAS No. 27159-32-6

  • Cat. No. CS-0217778
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(Benzylamino)propan-2-ol|CS-0217778

Structure of 27159-32-6

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General Information

  • CAS No. 27159-32-6
  • Cat. No. CS-0217778
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₅NO
  • Molecular Weight 165.23
  • Synonym(s) 2-Propanol, 1-((phenylmethyl)amino)-
  • SMILES CC(CNCC1=CC=CC=C1)O

Description

This benzylamino-propanol derivative features a primary amine linked to a benzylic carbon, integrating a reactive handle with enhanced solubility and stability. The pendant hydroxyl group enables hydrogen bonding and facilitates derivatization. This scaffold supports synthesis of bioactive molecules and serves as a chiral building block in medicinal chemistry.

Application

1-(Benzylamino)propan-2-ol serves as a versatile chiral building block in medicinal chemistry, enabling efficient access to β-amino alcohol scaffolds through reductive amination and cyclization protocols. Its benzylamine functionality offers enhanced solubility and compatibility with standard coupling reactions, while the secondary alcohol facilitates selective derivatization and protection strategies. The molecule exhibits good bench stability and is readily purified by column chromatography, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1
    • null|null
      100-46-9
    • null|null
      75-56-9
    • ~83%
    • In-stock
      1-(Benzylamino)propan-2-ol|CS-0217778
      27159-32-6

    References

    • Cepanec, Ivica; Litvic, Mladen; Mikuldas, Hrvoje; Bartolincic, Anamarija; Vinkovic, Vladimir Tetrahedron, 2003 , vol. 59, # 14 p. 2435 - 2439
  • Route2
    • null|null
      5456-01-9
    • ~%
    • In-stock
      1-(Benzylamino)propan-2-ol|CS-0217778
      27159-32-6

    References

    • SCHERING CORPORATION Patent: WO2006/60461 A1, 2006 ; Location in patent: Page/Page column 148-149 ; WO 2006/060461 A1
  • Route3
    • null|null
      100-52-7
    • In-stock
      1-Aminopropan-2-ol|CS-W016685
      78-96-6
    • ~%
    • In-stock
      1-(Benzylamino)propan-2-ol|CS-0217778
      27159-32-6

    References

    • Freifelder et al. Journal of the American Chemical Society, 1958 , vol. 80, p. 4320,4323

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.26
  • LogP   1.157
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   4

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