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CS-W001157 4
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2-(Methylsulfonyl)imidazole

  • CAS No. 27098-98-2

  • Cat. No. CS-0130450
  • Molecule weight146.17
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(Methylsulfonyl)imidazole|CS-0130450

Structure of 27098-98-2

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General Information

  • CAS No. 27098-98-2
  • Cat. No. CS-0130450
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₆N₂O₂S
  • Molecular Weight 146.17
  • Synonym(s) 2-Methylsulfonyl-imidazole
  • SMILES O=S(C1=NC=CN1)(C)=O

Description

2-(Methylsulfonyl)imidazole is a bench-stable heterocyclic reagent featuring a sulfone group that enhances polarity and metabolic stability. This imidazole derivative serves as a versatile scaffold in medicinal chemistry, where the methylsulfonyl moiety facilitates hydrogen bonding and improves solubility. It integrates readily into bioactive molecules during late-stage functionalization.

Application

2-(Methylsulfonyl)imidazole serves as a versatile building block in medicinal chemistry, enabling the introduction of a polar, metabolically stable sulfone group adjacent to an imidazole core. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient incorporation into drug-like scaffolds. The molecule functions effectively in late-stage functionalization and provides enhanced solubility and bioavailability in target compounds.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   62.82
  • LogP   -0.1868
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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