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CS-W001157 4
Total: USD 88.00

5-(4-Methoxyphenyl)-1h-pyrazole

  • CAS No. 27069-17-6

  • Cat. No. CS-0126505
  • Purity≥95%
  • MDL No.MFCD00112008

*For research and further manufacturing use only, not for direct human use.

5-(4-Methoxyphenyl)-1h-pyrazole|CS-0126505

Structure of 27069-17-6

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General Information

  • CAS No. 27069-17-6
  • Cat. No. CS-0126505
  • Purity ≥95%
  • MDL No. MFCD00112008
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀N₂O
  • Molecular Weight 174.20
  • Synonym(s) 3-(4-Methoxyphenyl)Pyrazole
  • SMILES COC1=CC=C(C2=CC=NN2)C=C1

Description

5-(4-Methoxyphenyl)-1H-pyrazole features a conjugated pyrazole core linked to an electron-rich methoxy-substituted phenyl group, enhancing stability and solubility in organic media. This scaffold integrates readily into bioactive molecule design, offering favorable electronic properties for pharmaceutical and materials applications.

Application

5-(4-Methoxyphenyl)-1H-pyrazole serves as a versatile scaffold for medicinal chemistry and materials science, enabling efficient construction of biologically active heterocycles. Its stability under standard reaction conditions and tolerance to diverse functional groups facilitate downstream derivatization via C–H activation, Suzuki coupling, or electrophilic substitution. The methoxy-substituted phenyl ring enhances solubility and modulates electronic properties, supporting its use in drug discovery campaigns and functional molecular design.

Synthesis

  • Route1
    • null|null
      115270-35-4
    • ~88%
    • In-stock
      5-(4-Methoxyphenyl)-1h-pyrazole|CS-0126505
      27069-17-6

    References

    • Gogsig, Thomas M.; Nielsen, Dennis U.; Lindhardt, Anders T.; Skrydstrup, Troels Organic Letters, 2012 , vol. 14, # 10 p. 2536 - 2539
  • Route2

    References

    • Eisai Co., Ltd. Patent: EP1382603 A1, 2004 ; Location in patent: Page 43 ;
  • Route3

    References

    • Aggarwal, Varinder K.; De Vicente, Javier; Bonnert, Roger V. Journal of Organic Chemistry, 2003 , vol. 68, # 13 p. 5381 - 5383

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H318
Precautionary Statements : P280-P305+P351+P338

Quality Control

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Computational Chemistry Data

  • TPSA   37.91
  • LogP   2.0853
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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