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CS-W001157 4
Total: USD 88.00

2-((Dimethylamino)methyl)pyridin-3-ol

  • CAS No. 2168-13-0

  • Cat. No. CS-0136296
  • Molecule weight152.19
  • Purity≥98%
  • MDL No.MFCD00006347

*For research and further manufacturing use only, not for direct human use.

2-((Dimethylamino)methyl)pyridin-3-ol|CS-0136296

Structure of 2168-13-0

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General Information

  • CAS No. 2168-13-0
  • Cat. No. CS-0136296
  • Purity ≥98%
  • MDL No. MFCD00006347
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₂N₂O
  • Molecular Weight 152.19
  • Synonym(s) 2-(Dimethylaminomethyl)-3-hydroxy pyridine
  • SMILES OC1=CC=CN=C1CN(C)C

Description

This pyridinol derivative features a dimethylaminomethyl group at the 2-position, enhancing solubility and nucleophilicity. The phenolic hydroxyl enables hydrogen bonding and metal chelation, while the basic pyridine nitrogen supports coordination in catalytic systems. Bench-stable and moisture-tolerant, it serves as a modular scaffold for ligands and bioactive molecule synthesis.

Application

2-((Dimethylamino)methyl)pyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds through functional group interconversions. Its pendant hydroxyl and dimethylaminomethyl groups offer orthogonal reactivity, facilitating derivatization via etherification, alkylation, or coupling reactions. The compound exhibits good bench stability and compatibility with standard purification methods, supporting its use in multi-step syntheses and API development workflows.

Synthesis

  • Route1
    • In-stock
      3-Hydroxypyridine|CS-W009147
      109-00-2
    • null|null
      50-00-0
    • null|null
      124-40-3
    • ~66%
    • In-stock
      2-((Dimethylamino)methyl)pyridin-3-ol|CS-0136296
      2168-13-0

    References

    • Takeda Pharmaceutical Company Limited Patent: EP2100895 A1, 2009 ; Location in patent: Page/Page column 74-75 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   36.36
  • LogP   0.8488
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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