Lot numbers can be found on the outside label of a product:
2,5-Dichloro-3,6-dimethylpyrazine
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CAS No. 27023-19-4
- Cat. No. CS-0450543
- Purity≥98%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 27023-19-4
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General Information
- CAS No. 27023-19-4
- Cat. No. CS-0450543
- Purity ≥98%
- MDL No. None
- Storage 4°C, stored under nitrogen
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₆Cl₂N₂
- Molecular Weight 177.03
- Synonym(s) Pyrazine,2,5-dichloro-3,6-dimethyl
- SMILES CC1=NC(=C(C)N=C1Cl)Cl
Description
2,5-Dichloro-3,6-dimethylpyrazine features a rigid pyrazine core substituted with chlorine and methyl groups at strategic positions, delivering enhanced stability and tunable reactivity. This electron-deficient heterocycle serves as a valuable scaffold in synthetic medicinal chemistry, enabling efficient coupling reactions under mild conditions.
Application
2,5-Dichloro-3,6-dimethylpyrazine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling the construction of substituted pyrazine scaffolds via palladium-catalyzed cross-coupling reactions. Its halogenated positions offer high reactivity in Suzuki-Miyaura and Stille couplings, while the methyl groups enhance solubility and metabolic stability. The compound exhibits excellent bench stability and is readily purified by flash chromatography, facilitating integration into multi-step synthetic sequences.
Synthesis
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Route1
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In-stock
5625-46-7 - ~69%
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In-stock
27023-19-4
References
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Wang, Han; Wen, Kun; Wang, Le; Xiang, Ye; Xu, Xiaocheng; Shen, Yongjia; Sun, Zhihua Molecules, 2012 , vol. 17, # 4 p. 4533 - 4544
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Route2
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100449-89-6 - ~%
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In-stock
27023-19-4
References
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Karmas; Spoerri Journal of the American Chemical Society, 1956 , vol. 78, p. 4071,4076
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Route3
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16289-18-2 - ~%
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In-stock
27023-19-4
References
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Karmas; Spoerri Journal of the American Chemical Society, 1956 , vol. 78, p. 4071,4076
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 25.78
- LogP 2.40024
- H_Acceptors 2
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
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