Fmoc-(S)-3-Amino-4-(2,4-dichloro-phenyl)-butyric acid

Name: Fmoc-(S)-3-Amino-4-(2,4-dichloro-phenyl)-butyric acid
Brand: ChemScene
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CAS No. 270063-49-5
Cat. No. CS-0061676
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Fmoc-(S)-3-Amino-4-(2,4-dichloro-phenyl)-butyric acid|CS-0061676

Structure of 270063-49-5

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General Information

CAS No. 270063-49-5
Cat. No. CS-0061676
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₅H₂₁Cl₂NO₄
Molecular Weight 470.34
Synonym(s) (S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(2,4-dichlorophenyl)butanoic acid
SMILES ClC=1C=CC(=C(C1)Cl)C[C@@H](CC(O)=O)NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O

Description

Fmoc-(S)-3-Amino-4-(2,4-dichloro-phenyl)-butyric acid is a specialized amino acid derivative featuring a fluorenylmethoxy carbonyl (Fmoc) protecting group and a sterically hindered aromatic moiety. This configuration enhances solubility in organic solvents and provides stability during solid-phase peptide synthesis. The electron-deficient dichlorophenyl ring supports efficient coupling reactions while minimizing side processes. Ideal for incorporating non-natural residues into bioactive peptides, this building block enables precise structural diversification.

Application

Fmoc-(S)-3-Amino-4-(2,4-dichloro-phenyl)-butyric acid serves as a versatile building block for the synthesis of bioactive peptides and heterocyclic scaffolds. The Fmoc group enables efficient solid-phase peptide synthesis, while the 2,4-dichlorophenyl moiety provides enhanced metabolic stability and favorable pharmacokinetic properties. This compound exhibits excellent bench stability, tolerates common reaction conditions, and facilitates straightforward purification—making it ideal for medicinal chemistry campaigns targeting kinase inhibitors and other therapeutic agents.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 75.63
LogP 5.9179
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 7

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Chloride

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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Fmoc-(S)-3-Amino-4-(2,4-dichloro-phenyl)-butyric acid

CAS No. 270063-49-5

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