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CS-W001157 4
Total: USD 88.00

5-Ethynylpyridine-3-carboxylic acid

  • CAS No. 1211533-87-7

  • Cat. No. CS-0158568
  • Molecule weight147.13
  • Purity≥96%
  • MDL No.MFCD18207405

*For research and further manufacturing use only, not for direct human use.

5-Ethynylpyridine-3-carboxylic acid|CS-0158568

Structure of 1211533-87-7

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General Information

  • CAS No. 1211533-87-7
  • Cat. No. CS-0158568
  • Purity ≥96%
  • MDL No. MFCD18207405
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅NO₂
  • Molecular Weight 147.13
  • Synonym(s) 5-ethynylnicotinic acid
  • SMILES C#CC1=CC(=CN=C1)C(=O)O

Description

5-Ethynylpyridine-3-carboxylic acid features a conjugated alkyne moiety flanked by a pyridine ring and a carboxylic acid group, enabling efficient copper-catalyzed click chemistry. This bifunctional scaffold integrates seamlessly into bioconjugation workflows, offering high reactivity under mild conditions with excellent stability in aqueous environments.

Application

5-Ethynylpyridine-3-carboxylic acid serves as a versatile building block for the synthesis of functionalized heterocycles and conjugated systems. The terminal alkyne group enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC), while the carboxylic acid facilitates direct amidation or esterification. Its stability under standard bench conditions and compatibility with diverse reaction environments make it ideal for modular assembly of bioactive scaffolds and materials precursors.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   0.7611
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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