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CS-W001157 4
Total: USD 88.00

Fmoc-(R)-3-Amino-4-(3-methyl-phenyl)-butyric acid

  • CAS No. 269398-84-7

  • Cat. No. CS-0061287
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Fmoc-(R)-3-Amino-4-(3-methyl-phenyl)-butyric acid|CS-0061287

Structure of 269398-84-7

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General Information

  • CAS No. 269398-84-7
  • Cat. No. CS-0061287
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₆H₂₅NO₄
  • Molecular Weight 415.48
  • Synonym(s) (R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(m-tolyl)butanoic acid
  • SMILES CC1=CC(C[C@@H](NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)CC(O)=O)=CC=C1

Description

Fmoc-(R)-3-Amino-4-(3-methyl-phenyl)-butyric acid is a sterically hindered, bench-stable amino acid derivative featuring a para-substituted phenyl ring and a protected α-amino group. This building block integrates seamlessly into peptide synthesis workflows, enabling efficient incorporation of hydrophobic, aromatic side chains with enhanced solubility and handling stability under standard conditions.

Application

Fmoc-(R)-3-Amino-4-(3-methylphenyl)butyric acid serves as a valuable building block for peptide synthesis, enabling the incorporation of sterically hindered, aromatic amino acids with defined stereochemistry. The Fmoc group provides orthogonal protection for the α-amino functionality, facilitating efficient sequential coupling in solid-phase and solution-phase workflows. Its benzyl-substituted side chain offers enhanced hydrophobicity and structural diversity for peptidomimetic design, while maintaining bench stability and compatibility with standard deprotection protocols.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   4.91952
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   7

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