2-Cyclopropylpyrimidin-4-amine

Name: 2-Cyclopropylpyrimidin-4-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 265324-26-3
Cat. No. CS-0179755
Purity≥97%
MDL No.MFCD11043794

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Cyclopropylpyrimidin-4-amine|CS-0179755

Structure of 265324-26-3

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General Information

CAS No. 265324-26-3
Cat. No. CS-0179755
Purity ≥97%
MDL No. MFCD11043794
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₉N₃
Molecular Weight 135.17
Synonym(s) 4-Pyrimidinamine, 2-cyclopropyl- (9CI)
SMILES NC1=NC(C2CC2)=NC=C1

Description

2-Cyclopropylpyrimidin-4-amine delivers a rigid, electron-rich pyrimidine core paired with a cyclopropyl substituent that enhances metabolic stability. This scaffold integrates readily into kinase inhibitors and pharmaceutical intermediates, offering improved solubility and target engagement in medicinal chemistry applications.

Application

2-Cyclopropylpyrimidin-4-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of pyrimidine-based scaffolds prevalent in kinase inhibitors and antiviral agents. Its cyclopropyl substituent enhances metabolic stability and modulates electronic properties, while the primary amine facilitates straightforward derivatization via alkylation, acylation, or coupling reactions. The compound exhibits good bench stability and is readily purified by chromatography or recrystallization, supporting its use in scalable synthesis.

Synthesis

Route1
- 61310-53-0
- ~%
- In-stock
  
  265324-26-3
References
- Amrien, Kurt; Hunziker, Daniel; Kuhn, Bernd; Mayweg, Alexander; Neidhart, Werner Patent: US2005/288308 A1, 2005 ; Location in patent: Page/Page column 8-9 ; US 20050288308 A1
Route2
- In-stock
  
  57297-29-7
- 920-37-6
- ~%
- In-stock
  
  265324-26-3
References
- Amrien, Kurt; Hunziker, Daniel; Kuhn, Bernd; Mayweg, Alexander; Neidhart, Werner Patent: US2005/288308 A1, 2005 ; Location in patent: Page/Page column 9 ; US 20050288308 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

TPSA 51.8
LogP 0.9362
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Key Words

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2-Cyclopropylpyrimidin-4-amine

CAS No. 265324-26-3

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