CRBN ligand-395

Name: CRBN ligand-395
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CAS No. 2641512-74-3
Cat. No. CS-0650759
Molecule weight308.81
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Structure of 2641512-74-3

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General Information

CAS No. 2641512-74-3
Cat. No. CS-0650759
Purity ≥98%
MDL No. None
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₆H₂₁ClN₂O₂
Molecular Weight 308.81
Synonym(s) None
SMILES Cl.O=C1NC(=O)C(C2=CC=C(C=C2)C3CCNCC3)CC1

Description

This piperidine-based heterocycle features a conjugated aryl-piperidine linkage and dual carbonyl functionality, delivering enhanced solubility and metabolic stability. The hydrochloride salt form improves crystallinity and handling, enabling efficient integration into medicinal chemistry campaigns targeting CNS disorders and kinase inhibition pathways.

Application

3-(4-(Piperidin-4-yl)phenyl)piperidine-2,6-dione hydrochloride serves as a versatile scaffold for medicinal chemistry campaigns, enabling efficient access to complex heterocyclic architectures. The molecule combines a rigid piperidine core with an arylpiperidine moiety, offering favorable solubility and stability for high-throughput synthesis. Its functional groups support diverse transformations, including reductive amination and amide coupling, facilitating rapid analog generation in drug discovery workflows.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 58.2
LogP 2.0956
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 2

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Life Science PROTAC Ligands for E3 Ligase

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

Drug Discovery Inflammation/Immunology IRAK4

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CRBN ligand-395

CAS No. 2641512-74-3

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