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Structure of 262593-63-5
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5-(Trifluoromethoxy)-1H-indole integrates a strongly electron-withdrawing trifluoromethoxy group at the 5-position of the indole scaffold, enhancing both metabolic stability and lipophilicity. This substitution pattern enables selective incorporation into bioactive molecules for medicinal chemistry campaigns targeting kinase inhibitors and CNS modulators. The compound exhibits excellent bench stability and solubility in common organic solvents, facilitating efficient coupling reactions under standard conditions.
5-(Trifluoromethoxy)-1H-indole serves as a valuable building block in medicinal chemistry, enabling direct functionalization at the C5 position of the indole core. Its trifluoromethoxy group imparts enhanced metabolic stability and modulates lipophilicity, facilitating its use in drug discovery campaigns. The compound exhibits good bench stability and compatibility with standard coupling reactions, making it well-suited for iterative synthesis of complex heterocyclic scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: