3-Chloro-2,6-difluorophenol

Name: 3-Chloro-2,6-difluorophenol
Brand: ChemScene
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CAS No. 261762-51-0
Cat. No. CS-0100722
Purity≥98%
MDL No.MFCD01631330

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 261762-51-0

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General Information

CAS No. 261762-51-0
Cat. No. CS-0100722
Purity ≥98%
MDL No. MFCD01631330
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃ClF₂O
Molecular Weight 164.54
Synonym(s) 3-CHLORO-2,6-DIFLUOROPHENOL 97
SMILES OC1=C(F)C=CC(Cl)=C1F

Description

3-Chloro-2,6-difluorophenol features a trifunctional aromatic core with orthogonal halogen substituents enabling selective coupling reactions. The electron-withdrawing chlorine and fluorine atoms enhance reactivity in nucleophilic substitution processes while maintaining stability under standard bench conditions. This compound serves as a key building block for pharmaceutical intermediates and agrochemicals requiring halogen-directed functionalization.

Application

3-Chloro-2,6-difluorophenol serves as a versatile building block in medicinal chemistry, enabling efficient construction of fluorinated aromatic scaffolds. Its ortho-fluoro substituents enhance metabolic stability and modulate electronic properties, while the phenolic hydroxyl group facilitates direct coupling reactions or derivatization. The molecule exhibits good bench stability and compatibility with standard cross-coupling protocols, making it a practical choice for synthesizing bioactive intermediates and functionalized heterocycles.

Synthesis

Route1
- 1435-44-5
- ~58%
- In-stock
  
  261762-51-0
References
- Angewandte Chemie - International Edition, , vol. 51, # 19 p. 4666 - 4670

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

TPSA 20.23
LogP 2.3238
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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3-Chloro-2,6-difluorophenol

CAS No. 261762-51-0

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