2-Chloro-4,6-difluorophenol

Name: 2-Chloro-4,6-difluorophenol
Brand: ChemScene
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CAS No. 2267-99-4
Cat. No. CS-0098693
Purity≥95%
MDL No.MFCD11501032

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 2267-99-4
Cat. No. CS-0098693
Purity ≥95%
MDL No. MFCD11501032
Storage RT, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃ClF₂O
Molecular Weight 164.54
Synonym(s) Phenol, 2-chloro-4,6-difluoro-
SMILES OC1=C(C=C(C=C1Cl)F)F

Description

2-Chloro-4,6-difluorophenol features a trifluorinated aromatic core with strategic halogen placement, enabling direct functionalization in late-stage synthesis. The ortho-chloro and para-fluoro substituents enhance reactivity while maintaining stability under standard conditions. This electron-deficient phenol serves as a key intermediate for agrochemicals and pharmaceuticals.

Application

2-Chloro-4,6-difluorophenol serves as a versatile building block in medicinal chemistry, enabling efficient construction of fluorinated heterocycles and bioactive scaffolds. Its orthogonal reactivity profile—combining electrophilic substitution compatibility with stable C–Cl and C–F bonds—facilitates direct functionalization in late-stage derivatization. The compound exhibits excellent bench stability, simplifies purification via crystallization, and functions reliably in coupling reactions, including Suzuki-Miyaura and Ullmann-type transformations, making it ideal for API intermediate synthesis.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 20.23
LogP 2.3238
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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2-Chloro-4,6-difluorophenol

CAS No. 2267-99-4

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