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CS-W001157 4
Total: USD 88.00

(3-Chloro-2,6-difluorophenyl)methanamine

  • CAS No. 261762-46-3

  • Cat. No. CS-0464973
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(3-Chloro-2,6-difluorophenyl)methanamine|CS-0464973

Structure of 261762-46-3

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General Information

  • CAS No. 261762-46-3
  • Cat. No. CS-0464973
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClF₂N
  • Molecular Weight 177.58
  • Synonym(s) 3-Chloro-2,6-difluorobenzylamine
  • SMILES C1=C(C(=C(CN)C(=C1)F)F)Cl

Description

(3-Chloro-2,6-difluorophenyl)methanamine is a bench-stable arylamine featuring electron-withdrawing chlorine and fluorine substituents that enhance reactivity in coupling processes. This trifluorinated benzylamine integrates readily into pharmaceutical intermediates, offering improved metabolic stability and solubility in polar reaction media.

Application

(3-Chloro-2,6-difluorophenyl)methanamine serves as a versatile building block in medicinal chemistry, enabling the construction of fluorinated aromatic scaffolds prevalent in agrochemicals and pharmaceuticals. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient incorporation into complex molecules. The ortho-fluoro substituents enhance metabolic stability, while the primary amine functions as a key handle for diversification via acylation, alkylation, or reductive amination.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.0769
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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