4-Chloro-3,5-difluoroaniline

Name: 4-Chloro-3,5-difluoroaniline
Brand: ChemScene
Availability: InStock
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CAS No. 2613-33-4
Cat. No. CS-0059224
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 2613-33-4

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Description

4-Chloro-3,5-difluoroaniline delivers a trifunctional aromatic scaffold with orthogonal reactivity. The para-chloro and ortho-fluoro substituents enable selective coupling under mild conditions. This electron-deficient aniline integrates readily into pharmaceutical intermediates and agrochemicals, offering enhanced metabolic stability and controlled reactivity in multi-step syntheses.

Application

4-Chloro-3,5-difluoroaniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of heterocyclic scaffolds via standard coupling reactions. Its electron-deficient aromatic ring enhances reactivity in nucleophilic substitution and palladium-catalyzed cross-coupling processes, while the amine functionality provides a reliable handle for derivatization. Bench-stable and readily purified, it facilitates scalable synthesis of complex targets with high functional group tolerance.

General Information

CAS No. 2613-33-4
Cat. No. CS-0059224
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄ClF₂N
Molecular Weight 163.55
Synonym(s) 4-CHLORO-3,5-DIFLUORO-PHENYLAMINE
SMILES NC1=CC(F)=C(Cl)C(F)=C1

Computational Chemistry Data

TPSA 26.02
LogP 2.2004
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P302+P352-P304+P340

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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4-Chloro-3,5-difluoroaniline

CAS No. 2613-33-4

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