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CS-W001157 4
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2,3,3,5-Tetramethyl-3H-indole

  • CAS No. 25981-82-2

  • Cat. No. CS-0073036
  • Purity≥97%
  • MDL No.MFCD03093020

*For research and further manufacturing use only, not for direct human use.

2,3,3,5-Tetramethyl-3H-indole|CS-0073036

Structure of 25981-82-2

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General Information

  • CAS No. 25981-82-2
  • Cat. No. CS-0073036
  • Purity ≥97%
  • MDL No. MFCD03093020
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₅N
  • Molecular Weight 173.25
  • Synonym(s) 2,3,3,5-tetramethyl-3h-indol
  • SMILES CC1(C)C(C)=NC2=C1C=C(C)C=C2

Description

Fmoc-Gly-Gly-Phe-Gly-OH is a self-assembly of N- and C-protected tetrapeptide containing an Fmoc-protected amino group. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The compound is a protease cleavable linker used for antibody-drug conjugates (ADCs). Reagent grade, for research purpose.

Synthesis

  • Route1
    • null|null
      563-80-4
    • In-stock
      p-Tolylhydrazine hydrochloride|CS-W016192
      637-60-5
    • ~92%
    • In-stock
      2,3,3,5-Tetramethyl-3H-indole|CS-0073036
      25981-82-2

    References

    • Ivashenko, Oleksii; Van Herpt, Jochem T.; Rudolf, Petra; Feringa, Ben L.; Browne, Wesley R. Chemical Communications, 2013 , vol. 49, # 60 p. 6737 - 6739
  • Route2
    • null|null
      563-80-4
    • N-4-Methylphenylhydrazine|CS-0110658
      539-44-6
    • ~%
    • In-stock
      2,3,3,5-Tetramethyl-3H-indole|CS-0073036
      25981-82-2

    References

    • Arakawa, Sei'ichi; Kondo, Hirofumi; Seto, Jun'etsu Chemistry Letters, 1985 , p. 1805 - 1808
  • Route3
    • null|null
      119094-84-7
    • ~%
    • In-stock
      2,3,3,5-Tetramethyl-3H-indole|CS-0073036
      25981-82-2

    References

    • Traven; Miroshnikov; Chibisova; Barachevsky; Venidiktova; Strokach Russian Chemical Bulletin, 2005 , vol. 54, # 10 p. 2417 - 2424

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   12.36
  • LogP   3.37862
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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