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CS-W001157 4
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(3-Fluoro-2-hydroxyphenyl)boronic acid

  • CAS No. 259209-24-0

  • Cat. No. CS-0111946
  • Purity≥97%
  • MDL No.MFCD07781238

*For research and further manufacturing use only, not for direct human use.

(3-Fluoro-2-hydroxyphenyl)boronic acid|CS-0111946

Structure of 259209-24-0

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General Information

  • CAS No. 259209-24-0
  • Cat. No. CS-0111946
  • Purity ≥97%
  • MDL No. MFCD07781238
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆BFO₃
  • Molecular Weight 155.92
  • Synonym(s) Boronic acid, (3-fluoro-2-hydroxyphenyl)- (9CI)
  • SMILES OB(O)C1=CC=CC(F)=C1O

Description

This boronic acid features a fluorinated aryl ring paired with a hydroxyl group, enabling selective coupling in Suzuki-Miyaura reactions. The ortho-hydroxy functionality enhances stability and directs regiochemistry during palladium-catalyzed transformations.

Application

(3-Fluoro-2-hydroxyphenyl)boronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling efficient construction of biaryl scaffolds under mild conditions. The ortho-hydroxyl group enhances regioselectivity and facilitates chelation-assisted coupling, while the fluorine substituent provides metabolic stability and modulates electronic properties. Bench-stable and readily purified by recrystallization, it exhibits good functional group tolerance, making it ideal for late-stage diversification in medicinal chemistry and materials synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P233-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   60.69
  • LogP   -0.7889
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   1

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