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CS-W001157 4
Total: USD 88.00

2-Chloro-6-iodopyridine

  • CAS No. 258506-66-0

  • Cat. No. CS-0041633
  • Purity≥96%
  • MDL No.MFCD07784182

*For research and further manufacturing use only, not for direct human use.

2-Chloro-6-iodopyridine|CS-0041633

Structure of 258506-66-0

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General Information

  • CAS No. 258506-66-0
  • Cat. No. CS-0041633
  • Purity ≥96%
  • MDL No. MFCD07784182
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClIN
  • Molecular Weight 239.44
  • Synonym(s) None
  • SMILES ClC1=NC(I)=CC=C1

Description

2-Chloro-6-iodopyridine is a halogenated pyridine derivative featuring complementary reactive sites for cross-coupling. The chlorine and iodine substituents enable sequential functionalization, with the iodine group facilitating efficient Pd-catalyzed coupling and the chlorine offering orthogonal reactivity. This dual-halogenation pattern supports modular synthesis in medicinal chemistry and materials science.

Application

2-Chloro-6-iodopyridine serves as a versatile bifunctional building block in cross-coupling chemistry, enabling sequential functionalization at the 2- and 6-positions of the pyridine ring. The chlorine atom facilitates palladium-catalyzed coupling reactions under mild conditions, while the iodide group offers high reactivity in Suzuki, Stille, Negishi, and Sonogashira transformations. Its bench-stable nature and orthogonal reactivity profile make it ideal for constructing complex heterocyclic scaffolds in medicinal chemistry and materials science.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.3396
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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