2,5-Dichlorothiazolo[4,5-b]pyridine

Name: 2,5-Dichlorothiazolo[4,5-b]pyridine
Brand: ChemScene
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CAS No. 2567498-97-7
Cat. No. CS-0498188
Purity≥96%
MDL No.None

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FedEx Limited Quantities Ground	$0.00
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2,5-Dichlorothiazolo[4,5-b]pyridine|CS-0498188

Structure of 2567498-97-7

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General Information

CAS No. 2567498-97-7
Cat. No. CS-0498188
Purity ≥96%
MDL No. None
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₂Cl₂N₂S
Molecular Weight 205.06
Synonym(s) None
SMILES ClC1=NC2=C(S1)C=CC(Cl)=N2

Description

2,5-Dichlorothiazolo[4,5-b]pyridine features a fused heterocyclic core combining thiazole and pyridine rings, bearing chlorine substituents at key positions for enhanced reactivity. This electron-deficient scaffold integrates readily into synthetic sequences requiring polarizable, planar platforms. The molecule exhibits bench-stable handling characteristics and serves as a strategic building block in the development of functionalized heteroaromatic systems.

Application

2,5-Dichlorothiazolo[4,5-b]pyridine serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of complex scaffolds through palladium-catalyzed cross-coupling reactions. Its electrophilic chloride substituents facilitate efficient functionalization under mild conditions, while the fused thiazole-pyridine core provides enhanced metabolic stability and favorable binding interactions. The compound exhibits excellent bench stability and compatibility with diverse functional groups, making it a practical choice for lead optimization and API synthesis.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 25.78
LogP 2.9981
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Thiazole compounds

Key Words

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2,5-Dichlorothiazolo[4,5-b]pyridine

CAS No. 2567498-97-7

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