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CS-W001157 4
Total: USD 88.00

4-(2-Pyridinyl)thiazol-2-amine

  • CAS No. 30235-26-8

  • Cat. No. CS-0072865
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(2-Pyridinyl)thiazol-2-amine|CS-0072865

Structure of 30235-26-8

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General Information

  • CAS No. 30235-26-8
  • Cat. No. CS-0072865
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇N₃S
  • Molecular Weight 177.23
  • Synonym(s) 4-Pyridin-2-yl-thiazol-2-ylamine
  • SMILES NC1=NC(C2=NC=CC=C2)=CS1

Description

4-(2-Pyridinyl)thiazol-2-amine integrates a pyridyl moiety with a thiazole core, delivering enhanced electronic coupling and directional binding. This heterocyclic scaffold exhibits strong hydrogen-bonding capacity and favorable solubility in polar solvents, enabling efficient incorporation into pharmaceutical intermediates and ligand design under standard conditions.

Application

4-(2-Pyridinyl)thiazol-2-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of bioactive scaffolds through palladium-catalyzed cross-coupling reactions. Its pyridyl-thiazole architecture provides enhanced solubility and favorable binding interactions, while the amine functionality facilitates derivatization and salt formation. Bench-stable and readily purified by recrystallization, it functions reliably in standard synthetic workflows for API development.

Synthesis

  • Route1
    • In-stock
      2-Bromo-1-(pyridin-2-yl)ethan-1-one|CS-0452146
      40086-66-6
    • null|null
      17356-08-0
    • ~68%
    • In-stock
      4-(2-Pyridinyl)thiazol-2-amine|CS-0072865
      30235-26-8

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 2 p. 560 - 564
  • Route2
    • In-stock
      2-(Bromoacetyl)pyridine hydrobromide|CS-W004138
      17570-98-8
    • null|null
      17356-08-0
    • ~89%
    • In-stock
      4-(2-Pyridinyl)thiazol-2-amine|CS-0072865
      30235-26-8

    References

    • Bioorganic and Medicinal Chemistry, , vol. 21, # 21 p. 6385 - 6397
  • Route3
    • 1-(Pyridin-2-yl)ethanone  Imatinib Impurity|CS-0167014
      1122-62-9
    • null|null
      17356-08-0
    • ~%
    • In-stock
      4-(2-Pyridinyl)thiazol-2-amine|CS-0072865
      30235-26-8

    References

    • Chemische Berichte, , vol. 92, p. 22,35

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   1.7873
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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