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Structure of 256518-97-5
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2-Chloro-5-iodo-1H-benzo[d]imidazole features a fused bicyclic core with orthogonal halogen substituents enabling selective cross-coupling. The electron-deficient imidazole ring facilitates palladium-catalyzed reactions, while the chlorine and iodine positions allow sequential functionalization. This scaffold delivers high reactivity under standard coupling conditions, offering efficient access to complex heterocyclic architectures in medicinal chemistry and materials science applications.
2-Chloro-5-iodo-1H-benzo[d]imidazole serves as a versatile building block for heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The chloro and iodo substituents allow sequential functionalization, with the iodo group exhibiting high reactivity in Suzuki, Stille, and Negishi couplings. Bench-stable and readily purified by recrystallization, it functions effectively in constructing biologically relevant imidazole scaffolds under standard reaction conditions.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: