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Structure of 2557-77-9
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3-Fluorobenzenethiol features a fluorinated aromatic ring linked to a reactive thiol group, enabling selective conjugation in bioorthogonal chemistry. The ortho-fluoro substitution enhances electrophilicity at the ring and improves metabolic stability. This bench-stable reagent integrates readily into peptide and polymer architectures via thiol-maleimide or gold-mediated coupling.
3-Fluorobenzenethiol serves as a versatile building block in medicinal chemistry and materials science, enabling the introduction of both fluorinated aromatic and thiol functionalities. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient synthesis of sulfide-linked biaryls and heterocyclic scaffolds. The ortho-fluorine substituent enhances metabolic stability and modulates electronic properties, making it valuable for optimizing pharmacophores in drug discovery pipelines.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2810
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301+H311+H331-H315-H319
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Precautionary Statements : P261-P264-P270-P271-P280-P361+P364-P405-P501
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Lot numbers can be found on the outside label of a product: