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CS-W001157 4
Total: USD 88.00

2-Fluorothiophenol

  • CAS No. 2557-78-0

  • Cat. No. CS-0040417
  • Purity≥98%
  • MDL No.MFCD00041419

*For research and further manufacturing use only, not for direct human use.

2-Fluorothiophenol|CS-0040417

Structure of 2557-78-0

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General Information

  • CAS No. 2557-78-0
  • Cat. No. CS-0040417
  • Purity ≥98%
  • MDL No. MFCD00041419
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅FS
  • Molecular Weight 128.17
  • Synonym(s) 2-Mercaptofluorobenzene
  • SMILES SC1=CC=CC=C1F

Description

2-Fluorothiophenol delivers a fluorinated thiophene scaffold with enhanced reactivity at the thiol site. The ortho-fluoro substitution imparts electronic modulation and improved metabolic stability, making it valuable for bioconjugation and synthetic intermediates in medicinal chemistry.

Application

2-Fluorothiophenol serves as a versatile building block in synthetic organic chemistry, enabling the introduction of fluorinated thiophene motifs into complex molecules. Its reactive thiol group facilitates conjugate additions, metal-catalyzed couplings, and thioether formation under mild conditions. The ortho-fluorine substituent enhances metabolic stability and modulates electronic properties, making it valuable for medicinal chemistry and agrochemical scaffold development. Bench-stable and compatible with standard purification methods, it functions reliably in multi-step syntheses.

Synthesis

  • Route1
    • 2-[(2-fluorophenyl)sulfanyl]acetic acid|CS-0220848
      705-02-2
    • ~%
    • In-stock
      2-Fluorothiophenol|CS-0040417
      2557-78-0

    References

    • International Journal of Chemical Kinetics, , vol. 31, # 10 p. 683 - 688
  • Route2
    • null|null
      348-54-9
    • ~%
    • In-stock
      2-Fluorothiophenol|CS-0040417
      2557-78-0

    References

    • Collection of Czechoslovak Chemical Communications, , vol. 44, # 7 p. 2139 - 2155
  • Route3
    • 2-[(2-fluorophenyl)sulfanyl]acetic acid|CS-0220848
      705-02-2
    • ~%
    • In-stock
      2-Fluorothiophenol|CS-0040417
      2557-78-0
    • Glyoxalic acid 50%w/w in water|CS-W019807
      298-12-4

    References

    • International Journal of Chemical Kinetics, , vol. 27, # 5 p. 443 - 452

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H315-H319-H335
Precautionary Statements : P210-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   2.1144
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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