Lot numbers can be found on the outside label of a product:
1,5-Naphthyridine
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CAS No. 254-79-5
- Cat. No. CS-B0780
- Purity≥98%
- MDL No.MFCD00039727
*For research and further manufacturing use only, not for direct human use.
Structure of 254-79-5
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General Information
- CAS No. 254-79-5
- Cat. No. CS-B0780
- Purity ≥98%
- MDL No. MFCD00039727
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₆N₂
- Molecular Weight 130.15
- Synonym(s) Pyrido[1,5-b]pyridine
- SMILES C12=NC=CC=C1N=CC=C2
Description
1,5-Naphthyridine is a nitrogen-rich heterocycle featuring two pyridine-like rings fused at the 1,5-positions, offering strong basicity and enhanced π-electron delocalization. This structural motif enables robust coordination in metal complexes and serves as a key scaffold in organic semiconductors and catalytic ligands.
Application
1,5-Naphthyridine serves as a versatile heterocyclic building block in medicinal chemistry and catalysis, offering a rigid, planar scaffold with two nitrogen atoms positioned for orthogonal coordination. It functions as a key structural motif in kinase inhibitors and ligands for transition metal complexes, enabling efficient synthesis of bioactive molecules through standard cross-coupling and electrophilic substitution reactions. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for high-throughput screening and process-scale applications.
Synthesis
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Route1
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462-08-8 -
In-stock
56-81-5 - ~82%
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In-stock
254-79-5
References
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Chunavala, Kaushik C.; Adimurthy, Subbarayappa Synthetic Communications, 2011 , vol. 41, # 12 p. 1843 - 1851
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Route2
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462-08-8
- ~%
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In-stock
254-79-5
References
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US3960876 A1, ;
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Route3
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198549-21-2
- ~23%
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In-stock
254-79-5
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In-stock
13993-61-8
References
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Tetrahedron Letters, , vol. 38, # 43 p. 7499 - 7502
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H318-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 25.78
- LogP 1.6298
- H_Acceptors 2
- H_Donors 0
- Rotatable_Bonds 0
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