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CS-W001157 4
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tert-Butyl 3-(iodomethyl)azetidine-1-carboxylate

  • CAS No. 253176-94-2

  • Cat. No. CS-W014547
  • Molecule weight297.14
  • Purity≥97%
  • MDL No.MFCD09951816

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 3-(iodomethyl)azetidine-1-carboxylate|CS-W014547

Structure of 253176-94-2

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General Information

  • CAS No. 253176-94-2
  • Cat. No. CS-W014547
  • Purity ≥97%
  • MDL No. MFCD09951816
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₆INO₂
  • Molecular Weight 297.14
  • Synonym(s) 1-Boc-3-(iodomethyl)azetidine
  • SMILES O=C(N1CC(CI)C1)OC(C)(C)C

Description

tert-Butyl 3-(iodomethyl)azetidine-1-carboxylate features a reactive iodomethyl group on a strained azetidine ring, enabling efficient alkylation under mild conditions. This bench-stable reagent integrates readily into complex molecular architectures, offering high functional group tolerance and compatibility with diverse synthetic transformations in medicinal chemistry and chemical biology applications.

Application

tert-Butyl 3-(iodomethyl)azetidine-1-carboxylate serves as a versatile building block for constructing azetidine-containing scaffolds in medicinal chemistry. The iodoalkyl group enables efficient SN2-mediated functionalization, while the tert-butyl carbamate protects the nitrogen under standard conditions. Its bench-stable nature and compatibility with palladium-catalyzed cross-coupling reactions facilitate rapid diversification of azetidine cores in API development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.54
  • LogP   2.2883
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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