H-Lys(Fmoc)-OH hydrochloride

Name: H-Lys(Fmoc)-OH hydrochloride
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CAS No. 253138-02-2
Cat. No. CS-0660884
Purity≥98%
MDL No.MFCD05662355

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 253138-02-2

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General Information

CAS No. 253138-02-2
Cat. No. CS-0660884
Purity ≥98%
MDL No. MFCD05662355
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₁H₂₅ClN₂O₄
Molecular Weight 404.89
Synonym(s) None
SMILES O=C(NCCCC[C@H](N)C(O)=O)OCC1C2=CC=CC=C2C3=CC=CC=C13.Cl

Description

H-Lys(Fmoc)-OH (hydrochloride) features a fully protected lysine side chain, enabling reliable incorporation into peptide chains during solid-phase synthesis. The Fmoc group ensures orthogonal deprotection under mild basic conditions, while the hydrochloride salt enhances solubility and handling stability. This derivative streamlines sequence assembly with minimal epimerization risk.

Application

H-Lys(Fmoc)-OH (hydrochloride) serves as a key building block in peptide synthesis, enabling efficient incorporation of lysine residues with orthogonal protection. The Fmoc group provides stable, base-labile protection for the α-amino function, while the side-chain ε-amino group remains free for subsequent derivatization. This reagent exhibits excellent bench stability, compatibility with standard coupling protocols, and facilitates straightforward purification via crystallization or chromatography.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

TPSA 101.65
LogP 3.5291
H_Acceptors 4
H_Donors 3
Rotatable_Bonds 8

Other Classifications

Bioactive Molecules Peptides

Building Blocks Functional Group Fmoc

Building Blocks Functional Group Amide

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Lysine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

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H-Lys(Fmoc)-OH hydrochloride

CAS No. 253138-02-2

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