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3,5-Dimethoxyphenyl iodide

  • CAS No. 25245-27-6

  • Cat. No. CS-D1784
  • Purity≥96%
  • MDL No.MFCD08729270

*For research and further manufacturing use only, not for direct human use.

3,5-Dimethoxyphenyl iodide|CS-D1784

Structure of 25245-27-6

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General Information

  • CAS No. 25245-27-6
  • Cat. No. CS-D1784
  • Purity ≥96%
  • MDL No. MFCD08729270
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉IO₂
  • Molecular Weight 264.06
  • Synonym(s) Benzene,1-iodo-3,5-dimethoxy-
  • SMILES COC1=CC(OC)=CC(I)=C1

Description

3,5-Dimethoxyphenyl iodide offers a sterically hindered, electron-rich aryl iodide scaffold ideal for palladium-catalyzed cross-coupling reactions. The ortho-dimethoxy substitution enhances solubility and stability under standard conditions, enabling efficient C–C bond formation with minimal homocoupling. This bench-stable reagent streamlines synthesis in complex molecule construction.

Synthesis

  • Route1

    References

    • Panteleev, Jane; Huang, Richard Y.; Lui, Erica K. J.; Lautens, Mark Organic Letters, 2011 , vol. 13, # 19 p. 5314 - 5317
  • Route2

    References

    • Alberico, Dino; Rudolph, Alena; Lautens, Mark Journal of Organic Chemistry, 2007 , vol. 72, # 3 p. 775 - 781
  • Route3
    • null|null
      89981-17-9
    • ~93%
    • In-stock
      3,5-Dimethoxyphenyl iodide|CS-D1784
      25245-27-6

    References

    • Mariampillai, Brian; Alberico, Dino; Bidau, Valerie; Lautens, Mark Journal of the American Chemical Society, 2006 , vol. 128, # 45 p. 14436 - 14437

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   2.3084
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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