Lot numbers can be found on the outside label of a product:
2-Iodo-5-methoxyphenol
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CAS No. 41046-70-2
- Cat. No. CS-W021705
- Purity≥97%
- MDL No.MFCD12963849
*For research and further manufacturing use only, not for direct human use.
Structure of 41046-70-2
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General Information
- CAS No. 41046-70-2
- Cat. No. CS-W021705
- Purity ≥97%
- MDL No. MFCD12963849
- Storage -20°C, protect from light, stored under nitrogen
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₇IO₂
- Molecular Weight 250.03
- Synonym(s) 3-Methoxy-6-iodophenol
- SMILES COC1=CC(O)=C(I)C=C1
Description
2-Iodo-5-methoxyphenol serves as a key intermediate in the synthesis of bioactive heterocycles and functionalized aryl systems. The iodine substituent enables efficient cross-coupling reactions, while the methoxy group enhances solubility and directs electrophilic substitution. This bench-stable phenolic derivative combines reactivity with handling convenience for medicinal chemistry and materials applications.
Application
2-Iodo-5-methoxyphenol serves as a versatile building block in medicinal chemistry and synthetic organic chemistry, enabling palladium-catalyzed cross-coupling reactions such as Suzuki and Stille couplings. The iodide group provides high reactivity under standard conditions, while the phenolic hydroxyl and methoxy functionalities offer orthogonal sites for further derivatization. Its bench-stable nature and compatibility with common protecting group strategies facilitate efficient synthesis of complex heterocyclic scaffolds and bioactive molecules.
Synthesis
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Route1
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In-stock
150-19-6 - ~83%
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In-stock
41046-70-2
References
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Das, Biswanath; Krishnaiah, Maddeboina; Venkateswarlu, Katta; Reddy, V. Saidi Tetrahedron Letters, 2007 , vol. 48, # 1 p. 81 - 83
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References
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McNeilab, Inc. Patent: US4652584 A1, 1987 ;
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Route3
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81245-38-7 - ~%
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In-stock
41046-70-2
References
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Morice, Christophe; Domostoj, Mathias; Briner, Karin; Mann, Andre; Suffert, Jean; Wermuth, Camille-Georges Tetrahedron Letters, 2001 , vol. 42, # 37 p. 6499 - 6502
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Safety Information
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352
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Quality Control
Computational Chemistry Data
- TPSA 29.46
- LogP 2.0054
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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