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CS-W001157 4
Total: USD 88.00

H-Cyclopentyl-Gly-OH

  • CAS No. 2521-84-8

  • Cat. No. CS-W008530
  • Purity≥97%
  • MDL No.MFCD03788076

*For research and further manufacturing use only, not for direct human use.

H-Cyclopentyl-Gly-OH|CS-W008530

Structure of 2521-84-8

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General Information

  • CAS No. 2521-84-8
  • Cat. No. CS-W008530
  • Purity ≥97%
  • MDL No. MFCD03788076
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₃NO₂
  • Molecular Weight None
  • Synonym(s) None
  • SMILES O=C(O)[C@@H](N)C1CCCC1

Description

H-Cyclopentyl-Gly-OH delivers a rigid, conformationally constrained glycine surrogate with enhanced metabolic stability. The cyclopentyl ring imparts steric bulk and lipophilicity, enabling improved membrane permeability and target engagement in bioactive peptide design. This non-canonical amino acid integrates seamlessly into peptidomimetic scaffolds for drug discovery applications.

Application

H-Cyclopentyl-Gly-OH serves as a versatile building block for peptide synthesis, offering a rigid cyclopentyl moiety that modulates conformational flexibility and lipophilicity in bioactive peptides. Its stability under standard coupling conditions and compatibility with common protecting group strategies facilitate efficient incorporation into target molecules. The α-amino acid functionality enables straightforward amide bond formation, making it suitable for medicinal chemistry campaigns focused on peptidomimetics and scaffold diversification.

Synthesis

  • Route1
    • null|null
      112741-63-6
    • ~91%
    • In-stock
      H-Cyclopentyl-Gly-OH|CS-W008530
      2521-84-8

    References

    • Journal of the American Chemical Society, , vol. 110, # 5 p. 1547 - 1557
  • Route2
    • null|null
      546141-10-0
    • ~82%
    • In-stock
      H-Cyclopentyl-Gly-OH|CS-W008530
      2521-84-8

    References

    • Tetrahedron Letters, , vol. 44, # 13 p. 2683 - 2685
  • Route3

    References

    • Chemical communications (Cambridge, England), , # 3 p. 246 - 247

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   63.32
  • LogP   0.5885
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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