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N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N-methyl-L-threonine

  • CAS No. 252049-06-2

  • Cat. No. CS-0089868
  • Purity≥97%
  • MDL No.MFCD02094575

*For research and further manufacturing use only, not for direct human use.

N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N-methyl-L-threonine|CS-0089868

Structure of 252049-06-2

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General Information

  • CAS No. 252049-06-2
  • Cat. No. CS-0089868
  • Purity ≥97%
  • MDL No. MFCD02094575
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₀H₂₁NO₅
  • Molecular Weight 355.38
  • Synonym(s) None
  • SMILES C[C@@H](O)[C@@H](C(O)=O)N(C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C

Description

This fluorenylmethoxycarbonyl-protected threonine derivative features a sterically hindered methylated side chain and a bench-stable fluorenylmethyl carbamate group, enabling efficient incorporation into peptide chains under standard coupling conditions.

Application

N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N-methyl-L-threonine serves as a protected amino acid building block for peptide synthesis, enabling orthogonal Nα and Nε protection. The Fmoc group ensures stable storage and facile removal under mild basic conditions, while the N-methyl functionality enhances metabolic stability and modulates conformational preferences. Its well-defined stereochemistry and compatibility with standard coupling protocols facilitate efficient assembly of complex peptides and peptidomimetics.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   87.07
  • LogP   2.7013
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   5

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