Lot numbers can be found on the outside label of a product:
2,6-Dichloro-4-nitropyridine
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CAS No. 25194-01-8
- Cat. No. CS-W020683
- Purity≥98%
- MDL No.MFCD05670545
*For research and further manufacturing use only, not for direct human use.
Structure of 25194-01-8
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General Information
- CAS No. 25194-01-8
- Cat. No. CS-W020683
- Purity ≥98%
- MDL No. MFCD05670545
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₅H₂Cl₂N₂O₂
- Molecular Weight 192.99
- Synonym(s) T6NJ BG DNW FG [WLN]
- SMILES O=[N+](C1=CC(Cl)=NC(Cl)=C1)[O-]
Description
2,6-Dichloro-4-nitropyridine features a pyridine core functionalized with two chlorine atoms at the 2 and 6 positions and a nitro group at the 4 position. This electron-deficient heterocycle integrates readily into cross-coupling reactions, serving as a robust building block for pharmaceutical intermediates and agrochemicals under standard conditions.
Application
2,6-Dichloro-4-nitropyridine serves as a versatile building block in heterocyclic synthesis, enabling efficient functionalization at the 4-position via nucleophilic substitution. The electron-deficient pyridine ring facilitates regioselective reactions with amines, thiols, and other nucleophiles, while the dichloro substituents offer orthogonal reactivity for sequential transformations. Its bench stability and ease of purification make it well-suited for iterative synthesis of complex scaffolds relevant to medicinal chemistry and agrochemical development.
Synthesis
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Route1
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2587-00-0 - ~68%
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In-stock
25194-01-8
References
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Xuanzhu Pharmaco., Ltd. Patent: EP2524917 A1, 2012 ; Location in patent: Page/Page column 58-59 ;
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Route2
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2587-01-1
- ~%
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In-stock
25194-01-8
References
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US4453972 A1, ;
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Route3
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14432-16-7
- ~69%
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In-stock
25194-01-8
References
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Palmer, Andreas Marc; Muench, Gabriela; Brehm, Christof; Zimmermann, Peter Jan; Buhr, Wilm; Feth, Martin Philipp; Simon, Wolfgang Alexander Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 3 p. 1511 - 1530
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H317-H318-H335
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Precautionary Statements : P261-P264-P270-P271-P272-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 56.03
- LogP 2.2966
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 1
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Key Words
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