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CS-W001157 4
Total: USD 88.00

Dimethyl-1,3-oxazole-5-carboxylic acid

  • CAS No. 2510-37-4

  • Cat. No. CS-0049607
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Dimethyl-1,3-oxazole-5-carboxylic acid|CS-0049607

Structure of 2510-37-4

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General Information

  • CAS No. 2510-37-4
  • Cat. No. CS-0049607
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇NO₃
  • Molecular Weight 141.12
  • Synonym(s) 2,4-Dimethyl-5-oxazolecarboxylic Acid
  • SMILES CC1=NC(C)=C(O1)C(O)=O

Description

Dimethyl-1,3-oxazole-5-carboxylic acid features a stable oxazole core with dual methyl ester functionalities, enabling direct incorporation into heterocyclic synthesis. This bench-stable derivative delivers enhanced solubility and reactivity in transition-metal-catalyzed couplings, serving as a robust building block for bioactive molecule development.

Application

Dimethyl-1,3-oxazole-5-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling efficient access to oxazole-containing scaffolds via standard coupling and functionalization reactions. Its stability under ambient conditions and compatibility with diverse reaction systems facilitate straightforward incorporation into complex molecular architectures. The molecule functions effectively as a precursor for heterocyclic synthesis and supports downstream derivatization in API development workflows.

Synthesis

  • Route1
    • Ethyl 2,4-dimethyl-1,3-oxazole-5-carboxylate|CS-0218057
      23012-30-8
    • ~44%
    • In-stock
      Dimethyl-1,3-oxazole-5-carboxylic acid|CS-0049607
      2510-37-4

    References

    • Wyeth Patent: US2006/19965 A1, 2006 ; Location in patent: Page/Page column 22-23 ; US 20060019965 A1
  • Route2

    References

    • Yakugaku Zasshi, , vol. 76, p. 307 Chem.Abstr., , p. 13874
  • Route3
    • In-stock
      Benzamide|CS-Z0019
      55-21-0
    • EThyl 2-(acetyloxy)-3-oxobutanoate|CS-0715555
      18632-42-3
    • ~%
    • In-stock
      Dimethyl-1,3-oxazole-5-carboxylic acid|CS-0049607
      2510-37-4
    • 4-Methyl-2-phenyl-1,3-oxazole-5-carboxylic acid|CS-0263465
      91137-55-2

    References

    • Yakugaku Zasshi, , vol. 76, p. 307 Chem.Abstr., , p. 13874

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   63.33
  • LogP   0.98964
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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