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CS-W001157 4
Total: USD 88.00

1-Methylpiperidine-2,6-dione

  • CAS No. 25077-25-2

  • Cat. No. CS-0151200
  • Molecule weight127.14
  • Purity≥97%
  • MDL No.MFCD01725031

*For research and further manufacturing use only, not for direct human use.

1-Methylpiperidine-2,6-dione|CS-0151200

Structure of 25077-25-2

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General Information

  • CAS No. 25077-25-2
  • Cat. No. CS-0151200
  • Purity ≥97%
  • MDL No. MFCD01725031
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉NO₂
  • Molecular Weight 127.14
  • Synonym(s) 2,6-Piperidinedione, 1-methyl-
  • SMILES CN1C(=O)CCCC1=O

Description

1-Methylpiperidine-2,6-dione features a rigid, electron-deficient diketone core that enables direct incorporation into heterocyclic scaffolds. This bench-stable compound serves as a key synthon in medicinal chemistry, pairing efficiently with nucleophiles to construct complex nitrogen-containing architectures under mild conditions.

Application

1-Methylpiperidine-2,6-dione serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted piperidinone scaffolds via standard functionalization protocols. Its diketone motif offers orthogonal reactivity for selective transformations, while the methyl substitution enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for use in medicinal chemistry campaigns and API intermediate synthesis.

Synthesis

  • Route1

    References

    • Yoshifuji, Shigeyuki; Arakawa, Yukimi; Nitta, Yoshihiro Chemical & Pharmaceutical Bulletin, 1987 , vol. 35, # 1 p. 357 - 363
  • Route2
    • In-stock
      Glutarimide|CS-W023103
      1121-89-7
    • null|null
      74-88-4
    • ~98%
    • In-stock
      1-Methylpiperidine-2,6-dione|CS-0151200
      25077-25-2

    References

    • Marson; Khan; Porter Journal of Organic Chemistry, 2001 , vol. 66, # 14 p. 4771 - 4775
  • Route3
    • In-stock
      Glutaric acid|CS-W009536
      110-94-1
    • null|null
      74-89-5
    • ~%
    • In-stock
      1-Methylpiperidine-2,6-dione|CS-0151200
      25077-25-2
    • null|null
      56269-42-2

    References

    • Lukes; Smetackova Collection of Czechoslovak Chemical Communications, 1933 , vol. 5, p. 61,64 Full Text Show Details Hall et al. Journal of the American Chemical Society, 1958 , vol. 80, p. 6420,6421

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.38
  • LogP   0.1553
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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