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CS-W001157 4
Total: USD 88.00

Acid-C3-SSPy

  • CAS No. 250266-79-6

  • Cat. No. CS-0182091
  • Purity≥98%
  • MDL No.MFCD25961520

*For research and further manufacturing use only, not for direct human use.

Acid-C3-SSPy|CS-0182091

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General Information

  • CAS No. 250266-79-6
  • Cat. No. CS-0182091
  • Purity ≥98%
  • MDL No. MFCD25961520
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁NO₂S₂
  • Molecular Weight 229.32
  • Synonym(s) None
  • SMILES O=C(O)CCCSSC1=NC=CC=C1

Description

Acid-C3-SSPy delivers a robust disulfide-linked spacer for bioconjugation workflows, combining stable linkage with efficient cleavage under reducing conditions. The C3 aliphatic chain provides enhanced solubility and reduced aggregation, while the pyridyl thioether moiety enables site-specific conjugation. This reagent integrates seamlessly into antibody-drug conjugate development and protein labeling applications.

Application

Acid-C3-SSPy serves as a versatile bifunctional building block for conjugation and prodrug strategies, combining a C3-alkyl linker with a disulfide (SS) bridge and a carboxylic acid handle. The disulfide moiety enables cleavage under reducing conditions, while the acid group facilitates amide coupling or derivatization. Its stability in oxidizing environments and compatibility with standard peptide synthesis protocols make it ideal for targeted delivery systems and bioconjugation workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS05
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H318-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P312-P332+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   2.6867
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   6

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