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(2-pyridyldithio)-PEG1-hydrazine

  • CAS No. 111625-28-6

  • Cat. No. CS-0119697
  • Purity≥97%
  • MDL No.MFCD22551638

*For research and further manufacturing use only, not for direct human use.

(2-pyridyldithio)-PEG1-hydrazine|CS-0119697

Structure of 111625-28-6

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General Information

  • CAS No. 111625-28-6
  • Cat. No. CS-0119697
  • Purity ≥97%
  • MDL No. MFCD22551638
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉NOS₂
  • Molecular Weight 187.28
  • Synonym(s) None
  • SMILES OCCSSC1=NC=CC=C1

Description

This hydrazine-functionalized reagent integrates a (2-pyridyldithio)-PEG1 spacer for site-specific conjugation. The pyridyl disulfide moiety enables selective cleavage under reducing conditions, while the hydrazine group facilitates stable linkage to carbonyl-containing biomolecules. Ideal for bioconjugation workflows requiring orthogonal functionalization and controlled release.

Application

(2-pyridyldithio)-PEG1-hydrazine serves as a versatile bifunctional linker for site-specific conjugation in synthetic biology and medicinal chemistry. The hydrazine group enables selective reaction with carbonyl functionalities, while the pyridyldithio moiety facilitates disulfide exchange under mild conditions. Its PEG1 spacer provides enhanced solubility and reduced steric hindrance, supporting efficient coupling and purification in peptide, protein, and antibody-drug conjugate workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H312-H315-H317-H318-H332-H412
Precautionary Statements : P261-P264-P270-P271-P272-P273-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.8142
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   4

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