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CS-W001157 4
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2-(Pyridyldithio)ethylamine hydrochloride

  • CAS No. 106139-15-5

  • Cat. No. CS-6477
  • Purity≥97%
  • MDL No.MFCD01863453

*For research and further manufacturing use only, not for direct human use.

2-(Pyridyldithio)ethylamine hydrochloride|CS-6477

Structure of 106139-15-5

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General Information

  • CAS No. 106139-15-5
  • Cat. No. CS-6477
  • Purity ≥97%
  • MDL No. MFCD01863453
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₁ClN₂S₂
  • Molecular Weight 222.76
  • Synonym(s) (S)-2-Pyridylthio Cysteamine Hydrochloride
  • SMILES NCCSSC1=NC=CC=C1.[H]Cl

Description

2-(Pyridyldithio)ethylamine (hydrochloride) features a pyridyl-thiol group that enables selective, reversible conjugation with cysteine residues in proteins. This reagent integrates efficiently into site-specific bioconjugation workflows, offering stable linkage under physiological conditions while maintaining solubility and ease of handling.

Application

2-(Pyridyldithio)ethylamine (hydrochloride) serves as a versatile bifunctional reagent for site-specific conjugation and protein labeling. The pyridyldithio group enables efficient disulfide exchange with thiol-containing biomolecules under mild conditions, while the primary amine facilitates coupling to activated carboxylates or aldehydes. Its hydrochloride salt form enhances solubility and bench stability, simplifying handling in aqueous-based workflows. Functions effectively in antibody-drug conjugate synthesis and bioconjugation protocols requiring orthogonal functionalization.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.2024
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   4

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