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(5-Nitrofuran-2-yl)methanol

  • CAS No. 2493-04-1

  • Cat. No. CS-0147463
  • Purity≥96%
  • MDL No.MFCD00272267

*For research and further manufacturing use only, not for direct human use.

(5-Nitrofuran-2-yl)methanol|CS-0147463

Structure of 2493-04-1

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General Information

  • CAS No. 2493-04-1
  • Cat. No. CS-0147463
  • Purity ≥96%
  • MDL No. MFCD00272267
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅NO₄
  • Molecular Weight 143.10
  • Synonym(s) 5-Nitrofurfuryl alcohol
  • SMILES O=[N+]([O-])C1=CC=C(CO)O1

Application

(5-Nitrofuran-2-yl)methanol serves as a versatile building block for nitrofuran derivatives, enabling efficient functionalization at the 5-position. Its aldehyde functionality facilitates nucleophilic additions and reductive aminations, while the nitro group supports subsequent transformations in heterocyclic synthesis. The compound exhibits good bench stability and is compatible with standard purification methods, making it suitable for use in medicinal chemistry campaigns targeting antimicrobial scaffolds.

Synthesis

  • Route1

    References

    • Nagendra; Madhu; Vishwanatha; Sureshbabu, Vommina V. Tetrahedron Letters, 2012 , vol. 53, # 38 p. 5059 - 5063
  • Route2

    References

    • Berry, Jane M.; Watson, Corrine Y.; Whish, William J. D.; Threadgill, Michael D. Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 8 p. 1147 - 1156
  • Route3
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      5407-68-1
    • ~%
    • In-stock
      (5-Nitrofuran-2-yl)methanol|CS-0147463
      2493-04-1

    References

    • Gilman; Wright Journal of the American Chemical Society, 1931 , vol. 53, p. 1923

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   76.51
  • LogP   0.6801
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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