3-(2,4-Dimethoxybenzyl)dihydropyrimidine-2,4(1H,3H)-dione

Name: 3-(2,4-Dimethoxybenzyl)dihydropyrimidine-2,4(1H,3H)-dione
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CAS No. 2490430-37-8
Cat. No. CS-0802254
Purity≥97%
MDL No.MFCD32852436

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3-(2,4-Dimethoxybenzyl)dihydropyrimidine-2,4(1H,3H)-dione|CS-0802254

Structure of 2490430-37-8

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General Information

CAS No. 2490430-37-8
Cat. No. CS-0802254
Purity ≥97%
MDL No. MFCD32852436
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₁₆N₂O₄
Molecular Weight 264.28
Synonym(s) None
SMILES COC1=CC(OC)=C(C=C1)CN2C(=O)NCCC2=O

Description

This dihydropyrimidinone features a 2,4-dimethoxybenzyl substituent that enhances solubility and modulates electronic properties. The scaffold integrates readily into medicinal chemistry campaigns targeting kinase inhibition and CNS-penetrant therapeutics. Bench-stable and compatible with standard synthetic workflows.

Application

3-(2,4-Dimethoxybenzyl)dihydropyrimidine-2,4(1H,3H)-dione serves as a versatile scaffold for medicinal chemistry campaigns, enabling efficient access to dihydropyrimidinone-based heterocycles. The 2,4-dimethoxybenzyl group enhances solubility and modulates electronic properties, while the core dihydropyrimidinone framework supports facile derivatization via standard functional group transformations. Its bench-stable nature and compatibility with common reaction conditions make it a practical building block for library synthesis and lead optimization workflows.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Computational Chemistry Data

TPSA 67.87
LogP 1.1457
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 4

Other Classifications

Building Blocks Functional Group Urea

Building Blocks Functional Group Amide

Building Blocks Skeleton Aliphatic heterocycle compounds Other aliphatic heterocycles compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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3-(2,4-Dimethoxybenzyl)dihydropyrimidine-2,4(1H,3H)-dione

CAS No. 2490430-37-8

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