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CS-W001157 4
Total: USD 88.00

Aceglutamide

  • CAS No. 2490-97-3

  • Cat. No. CS-4621
  • Molecule weight188.18
  • Purity≥98%
  • MDL No.MFCD00038159

*For research and further manufacturing use only, not for direct human use.

Aceglutamide|CS-4621

Structure of 2490-97-3

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General Information

  • CAS No. 2490-97-3
  • Cat. No. CS-4621
  • Purity ≥98%
  • MDL No. MFCD00038159
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₂N₂O₄
  • Molecular Weight 188.18
  • Synonym(s) α-N-Acetyl-L-glutamine; N2-Acetylglutamine
  • SMILES O=C(N)CC[C@@H](C(O)=O)NC(C)=O

Description

Aceglutamide delivers a stable, bioactive glutamine analog featuring a protected amine and hydrolytically robust amide linkage. This derivative integrates seamlessly into peptide synthesis workflows, offering enhanced solubility and handling stability under standard conditions.

Application

Aceglutamide serves as a versatile glutamine bioisostere in medicinal chemistry, enabling peptide backbone modification with enhanced metabolic stability. Its amide-linked γ-glutamyl moiety facilitates incorporation into peptidomimetics and enzyme inhibitor scaffolds, offering improved solubility and proteolytic resistance. Functions effectively in solid-phase synthesis and solution-phase coupling protocols, demonstrating robust bench stability and compatibility with common protecting group strategies.

Synthesis

  • Route1
    • L-Glutamine Amino acid impurity|CS-1738303
      56-85-9
    • null|null
      108-24-7
    • ~98%
    • In-stock
      Aceglutamide|CS-4621
      2490-97-3

    References

    • Veera Reddy; Ravindranath Synthetic Communications, 1992 , vol. 22, # 2 p. 257 - 264

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   109.49
  • LogP   -1.1588
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   5

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