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Structure of 247569-56-8
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It is employed as a reactant involved in synthesis of β-1,3-dicarbonyl aldehydes via oxidation, knoevenagel condensation using a lysine catalyst, and cycloisomerization for the synthesis of trisubstituted furans. It is also a reactant for the fluorination by HF and iodosylbenzene, intramolecular Michael addition reactions and synthesis of diols. Also applied in the synthesis of diols via reduction of aromatic and aliphatic ketos esters6 and cross-coupling reactions for stereo selective synthesis of unsymmetrical 1,4-enediones.
2-Fluoro-5-(methanesulfonyl)benzoic acid serves as a versatile building block for medicinal chemistry and agrochemical synthesis, enabling direct incorporation of both fluorinated aromatic and sulfonate functionalities. The carboxylic acid group facilitates amide coupling and esterification, while the methanesulfonyl moiety provides excellent metabolic stability and modulates lipophilicity. Bench-stable and readily purified by recrystallization, it functions reliably in standard cross-coupling and electrophilic substitution workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501
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Lot numbers can be found on the outside label of a product: