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CS-W001157 4
Total: USD 88.00

4,6-Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)dibenzo[b,d]furan

  • CAS No. 246040-77-7

  • Cat. No. CS-0090582
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4,6-Bis((S)-4-phenyl-4,5-dihydrooxazol-2-yl)dibenzo[b,d]furan|CS-0090582

Structure of 246040-77-7

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General Information

  • CAS No. 246040-77-7
  • Cat. No. CS-0090582
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₀H₂₂N₂O₃
  • Molecular Weight 458.51
  • Synonym(s) (4S,4'S)-2,2'-(4,6-Dibenzofurandiyl)bis[4,5-dihydro-4-phenyloxazole]
  • SMILES C1(C=CC=C2C3=N[C@@H](C4=CC=CC=C4)CO3)=C2OC5=C1C=CC=C5C6=N[C@@H](C7=CC=CC=C7)CO6

Description

(S,S)-Ph-Dbfox is a bench-stable, chiral ligand featuring a sterically hindered biaryl scaffold with a phosphine moiety and a dibenzofuran oxide framework. This configuration enables high enantioselectivity in palladium-catalyzed cross-coupling reactions, particularly in Suzuki-Miyaura processes where precise stereocontrol is critical.

Application

(S,S)-Ph-Dbfox serves as a highly effective chiral ligand in asymmetric catalysis, enabling enantioselective transformations such as allylic alkylation and conjugate addition. Its robust bench stability and well-defined stereochemistry facilitate reproducible high enantiomeric excesses, making it a practical choice for scalable synthesis of chiral building blocks in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   56.32
  • LogP   6.6222
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   4

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