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CS-W001157 4
Total: USD 88.00

4,6-Bis((R)-4-phenyl-4,5-dihydrooxazol-2-yl)dibenzo[b,d]furan

  • CAS No. 195433-00-2

  • Cat. No. CS-0103850
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4,6-Bis((R)-4-phenyl-4,5-dihydrooxazol-2-yl)dibenzo[b,d]furan|CS-0103850

Structure of 195433-00-2

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General Information

  • CAS No. 195433-00-2
  • Cat. No. CS-0103850
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₀H₂₂N₂O₃
  • Molecular Weight 458.51
  • Synonym(s) (4R,4'R)-2,2'-(4,6-Dibenzofurandiyl)bis[4,5-dihydro-4-phenyloxazole]
  • SMILES C1(C=CC=C2C3=N[C@H](C4=CC=CC=C4)CO3)=C2OC5=C1C=CC=C5C6=N[C@H](C7=CC=CC=C7)CO6

Description

(R,R)-Ph-Dbfox is a bench-stable, chiral diphosphine ligand featuring two phenyl-substituted dbfox units, enabling efficient asymmetric catalysis in palladium-catalyzed cross-coupling reactions. The rigid, electron-rich scaffold enhances enantioselectivity and catalyst longevity under standard conditions.

Application

(R,R)-Ph-Dbfox serves as a highly enantioselective, bench-stable chiral ligand in palladium-catalyzed cross-coupling reactions. It enables efficient C–C bond formation in Suzuki-Miyaura and Negishi couplings with broad functional group tolerance. Its rigid biaryl backbone enhances stereocontrol, while the phosphine oxide moiety improves catalyst stability and facilitates purification. Widely adopted for constructing chiral pharmaceutical intermediates, it functions reliably in standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   56.32
  • LogP   6.6222
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   4

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