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CS-W001157 4
Total: USD 88.00

Methyl picolinate

  • CAS No. 2459-07-6

  • Cat. No. CS-W005458
  • Purity≥97%
  • MDL No.MFCD00038038

*For research and further manufacturing use only, not for direct human use.

Methyl picolinate|CS-W005458

Structure of 2459-07-6

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General Information

  • CAS No. 2459-07-6
  • Cat. No. CS-W005458
  • Purity ≥97%
  • MDL No. MFCD00038038
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₂
  • Molecular Weight 137.14
  • Synonym(s) None
  • SMILES C1=C(C(OC)=O)N=CC=C1

Description

Methyl picolinate features a pyridine ring bearing a methyl ester group, delivering enhanced solubility and stability in polar solvents. This combination enables efficient incorporation into synthetic scaffolds requiring nitrogen-directed reactivity. The electron-deficient heterocycle supports selective transformations under mild conditions, streamlining access to functionalized pyridine derivatives in medicinal chemistry applications.

Application

Methyl picolinate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to pyridine-based scaffolds. Its ester functionality facilitates selective transformations, including nucleophilic substitution and reduction, while maintaining stability under standard bench conditions. The molecule exhibits excellent functional group tolerance and is readily purified by distillation or column chromatography, making it well-suited for use in medicinal chemistry campaigns and heterocyclic synthesis.

Synthesis

  • Route1
    • null|null
      109-04-6
    • null|null
      67-56-1
    • null|null
      68-12-2
    • ~64%
    • In-stock
      Methyl picolinate|CS-W005458
      2459-07-6
    • Nicorandil Impurity 58|CS-1001538
      14805-91-5

    References

    • Tetrahedron, , vol. 68, # 24 p. 4701 - 4709
  • Route2
    • In-stock
      2-Pyridinemethanol|CS-W020042
      586-98-1
    • null|null
      865-33-8
    • ~44%
    • In-stock
      Methyl picolinate|CS-W005458
      2459-07-6

    References

    • Powell, Adam B.; Stahl, Shannon S. Organic Letters, 2013 , vol. 15, # 19 p. 5072 - 5075
  • Route3
    • null|null
      38195-81-2
    • ~94%
    • In-stock
      Methyl picolinate|CS-W005458
      2459-07-6

    References

    • Singh, Sunil Kumar; Srinivasa Reddy; Mangle, Mangesh; Ravi Ganesh Tetrahedron, 2007 , vol. 63, # 1 p. 126 - 130

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   0.8682
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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