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CS-W001157 4
Total: USD 88.00

2-Oxopiperidine-4-carboxylic acid

  • CAS No. 24537-50-6

  • Cat. No. CS-W006096
  • Purity≥97%
  • MDL No.MFCD13659408

*For research and further manufacturing use only, not for direct human use.

2-Oxopiperidine-4-carboxylic acid|CS-W006096

Structure of 24537-50-6

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General Information

  • CAS No. 24537-50-6
  • Cat. No. CS-W006096
  • Purity ≥97%
  • MDL No. MFCD13659408
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉NO₃
  • Molecular Weight 143.14
  • Synonym(s) None
  • SMILES O=C1CC(C(O)=O)CCN1

Description

2-Oxopiperidine-4-carboxylic acid features a rigid, electron-deficient piperidine core with a strategically positioned carbonyl and carboxylic acid group. This bifunctional scaffold enables direct integration into peptide-like architectures and serves as a key building block in medicinal chemistry for constrained peptidomimetics.

Application

2-Oxopiperidine-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of saturated heterocyclic scaffolds found in bioactive molecules. Its functional group combination—ketone and carboxylic acid—facilitates diverse transformations including reductive amination, amidation, and cyclization reactions. The compound exhibits good bench stability and is amenable to standard purification methods, supporting its use in multi-step synthetic sequences for API development.

Synthesis

  • Route1

    References

    • TAKEDA PHARMACEUTICAL COMPANY LIMITED; MATSUMOTO, Shigemitsu; ONO, Koji; TOMINARI, Yusuke; KATOH, Taisuke; MIWA, Kazuhiro; HASUOKA, Atsushi; IMAMURA, Shinichi Patent: WO2013/18929 A1, 2013 ; Location in patent: Paragraph 0532 ; WO 2013/018929 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   66.4
  • LogP   -0.4028
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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